Extreme hypofractionation for newly diagnosed glioblastoma: rationale, dose, techniques, and outcomes
نویسندگان
چکیده
منابع مشابه
ROLe Of beVacizumab iN NewLy diagNOsed gLiObLastOma
Chemoradiation (CRT) with temozolomide (TMZ/CRT+TMZ) is the standard of care for newly diagnosed glioblastoma (GBM). This phase III trial, conducted by the Radiation Therapy Oncology Group (RTOG), North Central Cancer Treatment Group (NCCTG) and Eastern Cooperative Oncology Group (ECOG), evaluated whether adding bevacizumab (Bev) to standard CRT improves overall survival (OS) or progression-fre...
متن کاملCase-Based Review: newly diagnosed glioblastoma
Department of Neurology and Division of Medical Oncology, Mayo Clinic, Rochester, Minnesota (D.R.J.); Department of Radiation Oncology, University of California, San Francisco, California (S.E.F.); Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota (C.G., A.R.); Department of Radiology, Mayo Clinic, Rochester, Minnesota (T.J.K.); Department of Neurological Surger...
متن کاملLaser interstitial thermal therapy for newly diagnosed and recurrent glioblastoma.
OBJECTIVE Glioblastoma (GBM) is the most common and deadly malignant primary brain tumor. Better surgical therapies are needed for newly diagnosed GBMs that are difficult to resect and for GBMs that recur despite standard therapies. The authors reviewed their institutional experience of using laser interstitial thermal therapy (LITT) for the treatment of newly diagnosed or recurrent GBMs. METHO...
متن کاملImproved Outcomes with Intensity Modulated Radiation Therapy Combined with Temozolomide for Newly Diagnosed Glioblastoma Multiforme
Purpose. Glioblastoma multiforme (GBM) is optimally treated by maximal debulking followed by combined chemoradiation. Intensity modulated radiation therapy (IMRT) is gaining widespread acceptance in other tumour sites, although evidence to support its use over three-dimensional conformal radiation therapy (3DCRT) in the treatment of gliomas is currently lacking. We examined the survival outcome...
متن کاملConcurrent temozolomide and dose-escalated intensity-modulated radiation therapy in newly diagnosed glioblastoma.
PURPOSE To determine the maximum-tolerated dose (MTD) of radiation (RT) with concurrent temozolomide in patients with newly diagnosed glioblastoma (GBM), to estimate their progression-free (PFS) and overall survival (OS), and to assess the role of (11)C methionine PET (MET-PET) imaging in predicting recurrence. EXPERIMENTAL DESIGN Intensity-modulated RT (IMRT) doses of 66 to 81 Gy, assigned t...
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ژورنال
عنوان ژورنال: Neuro-Oncology
سال: 2020
ISSN: 1522-8517,1523-5866
DOI: 10.1093/neuonc/noaa133